Potassium in PDB 1hkc: Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate

All present enzymatic activity of Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate:
2.7.1.1;

The structure of Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate, PDB code: 1hkc was solved by A.E.Aleshin, R.B.Honzatko, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.80
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	175.090, 175.090, 99.470, 90.00, 90.00, 120.00
R / Rfree (%)	17.4 / 24.1

The binding sites of Potassium atom in the Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate (pdb code 1hkc). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate, PDB code: 1hkc:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate within 5.0Å range: probe atom residue distance (Å) B Occ A:K921 b:40.7 occ:1.00 O A:VAL248 2.8 23.2 1.0 O A:LEU242 2.9 33.9 1.0 O A:GLY250 3.2 44.7 1.0 O A:ILE245 3.2 25.8 1.0 O A:HOH1058 3.3 53.1 1.0 C A:ILE245 3.7 20.4 1.0 C A:LEU242 3.9 27.9 1.0 C A:VAL248 4.0 27.4 1.0 C A:GLY250 4.0 42.0 1.0 N A:GLY250 4.1 42.8 1.0 N A:ASP246 4.2 15.7 1.0 CD1 A:LEU242 4.2 31.3 1.0 CA A:ASP246 4.3 13.2 1.0 N A:ILE245 4.4 18.4 1.0 CA A:ILE245 4.5 15.6 1.0 CA A:ARG243 4.5 37.0 1.0 CA A:GLY250 4.6 42.0 1.0 C A:ASP246 4.6 18.6 1.0 C A:GLU249 4.6 44.3 1.0 N A:ARG243 4.7 34.2 1.0 N A:VAL248 4.7 24.3 1.0 CB A:ILE245 4.7 13.5 1.0 O A:ASP246 4.7 28.7 1.0 CA A:GLU249 4.7 43.2 1.0 N A:GLU249 4.8 36.2 1.0 C A:ARG243 4.8 40.0 1.0 N A:HIS244 4.8 37.9 1.0 CG A:LEU242 4.9 27.9 1.0 CA A:VAL248 4.9 23.8 1.0 N A:ASP251 4.9 44.6 1.0 CA A:LEU242 4.9 23.2 1.0

Potassium binding site 2 out of 2 in the Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Recombinant Human Hexokinase Type I Complexed with Glucose and Phosphate within 5.0Å range: probe atom residue distance (Å) B Occ A:K922 b:46.9 occ:1.00 O A:VAL696 2.9 43.9 1.0 O A:MET690 3.0 33.0 1.0 O A:VAL693 3.1 25.0 1.0 O A:GLY698 3.2 55.9 1.0 OD1 A:ASP699 3.5 83.4 1.0 C A:VAL693 3.8 23.0 1.0 C A:GLY698 3.8 54.0 1.0 N A:GLY698 4.0 53.2 1.0 C A:VAL696 4.0 46.1 1.0 C A:MET690 4.1 25.1 1.0 CA A:GLU694 4.3 29.2 1.0 O A:LYS691 4.3 38.9 1.0 N A:GLU694 4.3 23.9 1.0 C A:LYS691 4.4 36.5 1.0 CA A:LYS691 4.5 35.2 1.0 N A:ASP699 4.5 57.3 1.0 C A:GLU697 4.5 57.6 1.0 CA A:ASP699 4.6 59.7 1.0 CA A:GLY698 4.6 52.7 1.0 N A:VAL693 4.6 29.5 1.0 CA A:GLU697 4.6 59.9 1.0 CG A:ASP699 4.6 79.4 1.0 CA A:VAL693 4.7 24.1 1.0 N A:LYS691 4.7 29.2 1.0 C A:GLU694 4.8 30.3 1.0 N A:GLU697 4.8 54.9 1.0 N A:VAL696 4.9 36.6 1.0 CB A:VAL693 4.9 23.6 1.0

A.E.Aleshin, C.Zeng, H.D.Bartunik, H.J.Fromm, R.B.Honzatko. Regulation of Hexokinase I: Crystal Structure of Recombinant Human Brain Hexokinase Complexed with Glucose and Phosphate. J.Mol.Biol. V. 282 345 1998.
ISSN: ISSN 0022-2836
PubMed: 9735292
DOI: 10.1006/JMBI.1998.2017