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Potassium in PDB 8g20: Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327
Protein crystallography data
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327, PDB code: 8g20
was solved by
M.A.Tararina,
D.W.Christianson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.05 / 1.77 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 48.244, 55.544, 74.399, 73, 89.9, 82.82 |
| R / Rfree (%) | 19.3 / 23.1 |
Other elements in 8g20:
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327 also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327
(pdb code 8g20). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327, PDB code: 8g20:
Jump to Potassium binding site number: 1; 2; 3; 4;
In total 4 binding sites of Potassium where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327, PDB code: 8g20:
Jump to Potassium binding site number: 1; 2; 3; 4;
Potassium binding site 1 out of 4 in 8g20
Go back to
Potassium Binding Sites List in 8g20
Potassium binding site 1 out
of 4 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327 within 5.0Å range:
|
Potassium binding site 2 out of 4 in 8g20
Go back to
Potassium Binding Sites List in 8g20
Potassium binding site 2 out
of 4 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 2 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327 within 5.0Å range:
|
Potassium binding site 3 out of 4 in 8g20
Go back to
Potassium Binding Sites List in 8g20
Potassium binding site 3 out
of 4 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 3 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327 within 5.0Å range:
|
Potassium binding site 4 out of 4 in 8g20
Go back to
Potassium Binding Sites List in 8g20
Potassium binding site 4 out
of 4 in the Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 4 of Crystal Structure of Danio Rerio Histone Deacetylase 6 Catalytic Domain 2 Complexed with Inhibitor MZ327 within 5.0Å range:
|
Reference:
L.Sinatra,
A.Vogelmann,
F.Friedrich,
M.A.Tararina,
E.Neuwirt,
A.Colcerasa,
P.Konig,
L.Toy,
T.Z.Yesiloglu,
S.Hilscher,
L.Gaitzsch,
N.Papenkordt,
S.Zhai,
L.Zhang,
C.Romier,
O.Einsle,
W.Sippl,
M.Schutkowski,
O.Gross,
G.Bendas,
D.W.Christianson,
F.K.Hansen,
M.Jung,
M.Schiedel.
Development of First-in-Class Dual SIRT2/HDAC6 Inhibitors As Molecular Tools For Dual Inhibition of Tubulin Deacetylation. J.Med.Chem. V. 66 14787 2023.
ISSN: ISSN 0022-2623
PubMed: 37902787
DOI: 10.1021/ACS.JMEDCHEM.3C01385
Page generated: Mon Aug 12 23:45:08 2024
ISSN: ISSN 0022-2623
PubMed: 37902787
DOI: 10.1021/ACS.JMEDCHEM.3C01385
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