Potassium in PDB 7z4n: Plasmodium Falciparum Pyruvate Kinase Complexed with Pyruvate

All present enzymatic activity of Plasmodium Falciparum Pyruvate Kinase Complexed with Pyruvate:
2.7.1.40;

The structure of Plasmodium Falciparum Pyruvate Kinase Complexed with Pyruvate, PDB code: 7z4n was solved by M.Dillenberger, S.Rahlfs, K.Becker, K.Fritz-Wolf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.20 / 1.80
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	79.89, 112.4, 131.97, 90, 90, 90
R / Rfree (%)	20.5 / 24.5

The structure of Plasmodium Falciparum Pyruvate Kinase Complexed with Pyruvate also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Potassium atom in the Plasmodium Falciparum Pyruvate Kinase Complexed with Pyruvate (pdb code 7z4n). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Plasmodium Falciparum Pyruvate Kinase Complexed with Pyruvate, PDB code: 7z4n:

Potassium binding site 1 out of 1 in the Plasmodium Falciparum Pyruvate Kinase Complexed with Pyruvate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Plasmodium Falciparum Pyruvate Kinase Complexed with Pyruvate within 5.0Å range: probe atom residue distance (Å) B Occ A:K602 b:34.5 occ:1.00 OG A:SER71 2.6 33.5 1.0 OD1 A:ASP102 2.6 29.0 1.0 OD1 A:ASN69 2.7 29.6 1.0 O A:THR103 2.8 26.6 1.0 O A:HOH781 3.1 32.8 1.0 O A:HOH833 3.1 26.4 1.0 NZ A:LYS255 3.6 27.4 1.0 CG A:ASP102 3.6 26.7 1.0 C A:THR103 3.7 27.7 1.0 CG A:ASN69 3.7 29.0 1.0 CB A:SER71 3.7 36.3 1.0 O A:ASP102 3.8 27.1 1.0 OG A:SER228 3.8 27.9 1.0 N A:SER71 4.0 31.9 1.0 CA A:LYS104 4.2 31.8 1.0 C A:ASP102 4.2 31.8 1.0 ND2 A:ASN69 4.2 32.1 1.0 N A:LYS104 4.3 27.7 1.0 CA A:SER71 4.4 32.3 1.0 OE2 A:GLU107 4.4 35.1 1.0 CB A:ASP102 4.4 26.8 1.0 NH1 A:ARG67 4.4 31.7 1.0 OD2 A:ASP102 4.4 25.2 1.0 N A:THR103 4.5 25.1 1.0 O A:HOH776 4.6 32.5 1.0 O A:LYS104 4.6 30.9 1.0 CA A:THR103 4.7 26.0 1.0 C A:LYS104 4.7 27.5 1.0 N A:PHE70 4.9 28.0 1.0 CA A:ASP102 4.9 22.6 1.0 CB A:ASN69 4.9 26.1 1.0

M.Dillenberger, S.Rahlfs, K.Becker, K.Fritz-Wolf. Prominent Role of Cysteine Residues C49 and C343 in Regulating Plasmodium Falciparum Pyruvate Kinase Activity. Structure V. 30 1452 2022.
ISSN: ISSN 0969-2126
PubMed: 35998635
DOI: 10.1016/J.STR.2022.08.001