Potassium in PDB 7z4m: Plasmodium Falciparum Pyruvate Kinase Complexed with MG2+ and K+

All present enzymatic activity of Plasmodium Falciparum Pyruvate Kinase Complexed with MG2+ and K+:
2.7.1.40;

The structure of Plasmodium Falciparum Pyruvate Kinase Complexed with MG2+ and K+, PDB code: 7z4m was solved by M.Dillenberger, S.Rahlfs, K.Becker, K.Fritz-Wolf, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.74 / 1.90
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	89.2, 109.67, 134.14, 90, 90, 90
R / Rfree (%)	20.3 / 24.2

The structure of Plasmodium Falciparum Pyruvate Kinase Complexed with MG2+ and K+ also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Potassium atom in the Plasmodium Falciparum Pyruvate Kinase Complexed with MG2+ and K+ (pdb code 7z4m). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Plasmodium Falciparum Pyruvate Kinase Complexed with MG2+ and K+, PDB code: 7z4m:

Potassium binding site 1 out of 1 in the Plasmodium Falciparum Pyruvate Kinase Complexed with MG2+ and K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Plasmodium Falciparum Pyruvate Kinase Complexed with MG2+ and K+ within 5.0Å range: probe atom residue distance (Å) B Occ A:K602 b:68.8 occ:1.00 O A:HOH830 2.7 54.6 1.0 OD1 A:ASN69 2.7 50.3 1.0 OG A:SER71 2.8 67.6 1.0 OD1 A:ASP102 2.8 43.9 1.0 O A:THR103 3.1 40.8 1.0 O A:HOH847 3.2 57.6 1.0 CG A:ASP102 3.5 45.5 1.0 O A:HOH815 3.6 54.6 1.0 OG A:SER228 3.6 39.4 1.0 NZ A:LYS255 3.7 37.1 1.0 CG A:ASN69 3.7 43.6 1.0 CB A:SER71 3.8 50.4 1.0 C A:THR103 3.9 59.7 1.0 OD2 A:ASP102 4.0 46.9 1.0 NH1 A:ARG67 4.0 43.2 1.0 O A:ASP102 4.1 46.4 1.0 ND2 A:ASN69 4.2 49.1 1.0 N A:SER71 4.2 59.3 1.0 CB A:ASP102 4.2 35.2 1.0 CA A:LYS104 4.3 43.5 1.0 C A:ASP102 4.4 43.9 1.0 N A:LYS104 4.4 50.6 1.0 CA A:SER71 4.5 61.2 1.0 O A:LYS104 4.7 43.2 1.0 N A:THR103 4.8 41.7 1.0 O A:HOH733 4.8 41.3 1.0 CB A:ASN69 4.9 44.6 1.0 CB A:SER228 4.9 35.0 1.0 N A:PHE70 4.9 46.8 1.0 CA A:ASP102 4.9 41.7 1.0 C A:LYS104 4.9 39.0 1.0 CA A:ASN69 5.0 50.6 1.0 CA A:THR103 5.0 46.2 1.0

M.Dillenberger, S.Rahlfs, K.Becker, K.Fritz-Wolf. Prominent Role of Cysteine Residues C49 and C343 in Regulating Plasmodium Falciparum Pyruvate Kinase Activity. Structure V. 30 1452 2022.
ISSN: ISSN 0969-2126
PubMed: 35998635
DOI: 10.1016/J.STR.2022.08.001