Potassium in PDB 7sxp: G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution

The structure of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution, PDB code: 7sxp was solved by M.T.Banco, A.R.Ferre-D'amare, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.53 / 2.90
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	36.402, 36.402, 70.103, 90, 90, 120
R / Rfree (%)	24.1 / 27.7

The structure of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution also contains other interesting chemical elements:

Arsenic

(As)

2 atoms

The binding sites of Potassium atom in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution (pdb code 7sxp). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution, PDB code: 7sxp:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution within 5.0Å range: probe atom residue distance (Å) B Occ A:K101 b:49.4 occ:0.50 O6 A:G13 2.6 60.4 1.0 O6 A:G9 2.7 63.9 1.0 O6 A:G19 2.7 58.9 1.0 O6 A:G4 3.1 72.9 1.0 K A:K102 3.3 53.6 1.0 C6 A:G9 3.5 67.9 1.0 C6 A:G13 3.6 59.2 1.0 N1 A:G9 3.7 60.8 1.0 C6 A:G19 3.8 62.0 1.0 C6 A:G4 3.9 65.8 1.0 N1 A:G4 4.1 61.3 1.0 N1 A:G13 4.1 55.2 1.0 N1 A:G19 4.1 66.2 1.0 C5 A:G9 4.7 66.0 1.0 C5 A:G13 4.8 64.3 1.0 C2 A:G9 4.9 61.6 1.0

Potassium binding site 2 out of 3 in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution within 5.0Å range: probe atom residue distance (Å) B Occ A:K102 b:53.6 occ:1.00 O6 A:G4 2.6 72.9 1.0 O6 A:G20 2.7 65.2 1.0 O6 A:G9 2.7 63.9 1.0 O6 A:G5 2.7 56.0 1.0 O6 A:G13 2.7 60.4 1.0 O6 A:G14 2.8 65.4 1.0 O6 A:G19 2.8 58.9 1.0 O6 A:G10 2.8 73.4 1.0 K A:K101 3.3 49.4 0.5 K A:K103 3.5 68.7 1.0 C6 A:G13 3.6 59.2 1.0 C6 A:G5 3.6 65.5 1.0 C6 A:G9 3.6 67.9 1.0 C6 A:G19 3.6 62.0 1.0 C6 A:G4 3.6 65.8 1.0 C6 A:G20 3.6 64.5 1.0 C6 A:G10 3.7 70.6 1.0 C6 A:G14 3.7 64.6 1.0 N1 A:G9 3.8 60.8 1.0 N1 A:G5 3.9 67.6 1.0 N1 A:G4 3.9 61.3 1.0 N1 A:G13 4.0 55.2 1.0 N1 A:G20 4.0 61.7 1.0 N1 A:G19 4.0 66.2 1.0 N1 A:G10 4.1 63.2 1.0 N1 A:G14 4.2 66.2 1.0 C5 A:G13 4.7 64.3 1.0 C5 A:G19 4.7 65.4 1.0 C5 A:G10 4.8 63.4 1.0 C5 A:G5 4.8 65.3 1.0 C5 A:G9 4.9 66.0 1.0 C5 A:G4 4.9 63.0 1.0 C5 A:G20 4.9 62.2 1.0 C5 A:G14 4.9 64.3 1.0

Potassium binding site 3 out of 3 in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution within 5.0Å range: probe atom residue distance (Å) B Occ A:K103 b:68.7 occ:1.00 O6 A:G21 2.6 66.1 1.0 O6 A:G10 2.7 73.4 1.0 O6 A:G6 2.7 57.2 1.0 O6 A:G15 2.7 68.9 1.0 O6 A:G11 2.7 66.4 1.0 O6 A:G5 2.8 56.0 1.0 O6 A:G14 2.9 65.4 1.0 O6 A:G20 3.2 65.2 1.0 C6 A:G11 3.5 67.4 1.0 K A:K102 3.5 53.6 1.0 C6 A:G21 3.6 60.7 1.0 C6 A:G10 3.6 70.6 1.0 N1 A:G11 3.6 65.0 1.0 C6 A:G5 3.6 65.5 1.0 C6 A:G6 3.7 69.3 1.0 C6 A:G15 3.7 74.7 1.0 N1 A:G21 3.7 60.2 1.0 C6 A:G14 3.8 64.6 1.0 N1 A:G5 3.9 67.6 1.0 C6 A:G20 4.0 64.5 1.0 N1 A:G10 4.0 63.2 1.0 N1 A:G6 4.0 68.8 1.0 N1 A:G15 4.0 64.4 1.0 N1 A:G14 4.1 66.2 1.0 N1 A:G20 4.2 61.7 1.0 C5 A:G11 4.8 69.0 1.0 C5 A:G10 4.8 63.4 1.0 C5 A:G5 4.9 65.3 1.0 C2 A:G11 4.9 67.2 1.0 C5 A:G21 4.9 62.6 1.0 C5 A:G14 4.9 64.3 1.0

S.Balaratnam, Z.Torrey, D.R.Calabrese, M.T.Banco, K.Yazdani, X.Liang, A.R.Ferre-D'amare, D.Incarnato, J.S.Schneekloth Jr. Investigating the Nras 5' Utr As A Target For Small Molecules To Be Published.