Potassium in PDB 7pxh: Emodepside-Bound Drosophila Slo Channel
Other elements in 7pxh:
The structure of Emodepside-Bound Drosophila Slo Channel also contains other interesting chemical elements:
Potassium Binding Sites:
The binding sites of Potassium atom in the Emodepside-Bound Drosophila Slo Channel
(pdb code 7pxh). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the
Emodepside-Bound Drosophila Slo Channel, PDB code: 7pxh:
Jump to Potassium binding site number:
1;
2;
3;
4;
5;
6;
Potassium binding site 1 out
of 6 in 7pxh
Go back to
Potassium Binding Sites List in 7pxh
Potassium binding site 1 out
of 6 in the Emodepside-Bound Drosophila Slo Channel
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K1209
b:42.7
occ:0.50
|
O
|
C:GLY303
|
2.9
|
47.3
|
1.0
|
O
|
D:GLY303
|
2.9
|
48.2
|
1.0
|
O
|
B:GLY303
|
2.9
|
48.5
|
1.0
|
O
|
A:GLY303
|
2.9
|
47.6
|
1.0
|
O
|
C:TYR304
|
3.1
|
51.6
|
1.0
|
O
|
A:TYR304
|
3.2
|
52.0
|
1.0
|
O
|
B:TYR304
|
3.3
|
52.8
|
1.0
|
O
|
D:TYR304
|
3.4
|
53.2
|
1.0
|
K
|
A:K1210
|
3.6
|
42.7
|
0.5
|
C
|
C:TYR304
|
3.7
|
51.6
|
1.0
|
C
|
A:TYR304
|
3.7
|
52.0
|
1.0
|
C
|
B:TYR304
|
3.8
|
52.8
|
1.0
|
C
|
D:TYR304
|
3.9
|
53.2
|
1.0
|
C
|
C:GLY303
|
4.1
|
47.3
|
1.0
|
C
|
D:GLY303
|
4.1
|
48.2
|
1.0
|
C
|
A:GLY303
|
4.1
|
47.6
|
1.0
|
C
|
B:GLY303
|
4.1
|
48.5
|
1.0
|
CA
|
C:TYR304
|
4.3
|
51.6
|
1.0
|
N
|
C:GLY305
|
4.3
|
56.8
|
1.0
|
K
|
C:K1209
|
4.3
|
54.1
|
0.2
|
N
|
A:GLY305
|
4.3
|
56.0
|
1.0
|
CA
|
A:TYR304
|
4.4
|
52.0
|
1.0
|
N
|
B:GLY305
|
4.4
|
56.2
|
1.0
|
CA
|
B:TYR304
|
4.4
|
52.8
|
1.0
|
N
|
D:GLY305
|
4.5
|
57.9
|
1.0
|
CA
|
D:TYR304
|
4.5
|
53.2
|
1.0
|
CA
|
A:GLY305
|
4.6
|
56.0
|
1.0
|
CA
|
C:GLY305
|
4.6
|
56.8
|
1.0
|
CA
|
B:GLY305
|
4.7
|
56.2
|
1.0
|
N
|
C:TYR304
|
4.7
|
51.6
|
1.0
|
CA
|
D:GLY305
|
4.7
|
57.9
|
1.0
|
N
|
A:TYR304
|
4.8
|
52.0
|
1.0
|
N
|
B:TYR304
|
4.8
|
52.8
|
1.0
|
N
|
D:TYR304
|
4.8
|
53.2
|
1.0
|
|
Potassium binding site 2 out
of 6 in 7pxh
Go back to
Potassium Binding Sites List in 7pxh
Potassium binding site 2 out
of 6 in the Emodepside-Bound Drosophila Slo Channel
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K1210
b:42.7
occ:0.50
|
O
|
B:VAL302
|
2.7
|
49.0
|
1.0
|
O
|
D:VAL302
|
2.7
|
48.9
|
1.0
|
O
|
A:GLY303
|
2.7
|
47.6
|
1.0
|
O
|
C:GLY303
|
2.7
|
47.3
|
1.0
|
O
|
C:VAL302
|
2.8
|
48.0
|
1.0
|
O
|
B:GLY303
|
2.8
|
48.5
|
1.0
|
O
|
A:VAL302
|
2.8
|
48.7
|
1.0
|
O
|
D:GLY303
|
2.8
|
48.2
|
1.0
|
K
|
A:K1211
|
3.0
|
41.5
|
0.5
|
C
|
A:GLY303
|
3.6
|
47.6
|
1.0
|
C
|
C:GLY303
|
3.6
|
47.3
|
1.0
|
C
|
D:GLY303
|
3.6
|
48.2
|
1.0
|
K
|
A:K1209
|
3.6
|
42.7
|
0.5
|
C
|
B:GLY303
|
3.6
|
48.5
|
1.0
|
C
|
D:VAL302
|
3.8
|
48.9
|
1.0
|
CA
|
D:GLY303
|
3.8
|
48.2
|
1.0
|
C
|
B:VAL302
|
3.8
|
49.0
|
1.0
|
CA
|
A:GLY303
|
3.8
|
47.6
|
1.0
|
C
|
C:VAL302
|
3.8
|
48.0
|
1.0
|
C
|
A:VAL302
|
3.9
|
48.7
|
1.0
|
CA
|
B:GLY303
|
3.9
|
48.5
|
1.0
|
CA
|
C:GLY303
|
3.9
|
47.3
|
1.0
|
N
|
D:GLY303
|
4.2
|
48.2
|
1.0
|
N
|
A:GLY303
|
4.3
|
47.6
|
1.0
|
N
|
B:GLY303
|
4.3
|
48.5
|
1.0
|
N
|
C:GLY303
|
4.3
|
47.3
|
1.0
|
N
|
C:TYR304
|
4.7
|
51.6
|
1.0
|
N
|
A:TYR304
|
4.8
|
52.0
|
1.0
|
N
|
B:TYR304
|
4.8
|
52.8
|
1.0
|
N
|
D:TYR304
|
4.8
|
53.2
|
1.0
|
|
Potassium binding site 3 out
of 6 in 7pxh
Go back to
Potassium Binding Sites List in 7pxh
Potassium binding site 3 out
of 6 in the Emodepside-Bound Drosophila Slo Channel
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K1211
b:41.5
occ:0.50
|
O
|
C:VAL302
|
2.9
|
48.0
|
1.0
|
O
|
D:THR301
|
2.9
|
53.1
|
1.0
|
O
|
B:THR301
|
2.9
|
53.5
|
1.0
|
O
|
A:THR301
|
2.9
|
52.9
|
1.0
|
O
|
A:VAL302
|
3.0
|
48.7
|
1.0
|
K
|
A:K1210
|
3.0
|
42.7
|
0.5
|
O
|
C:THR301
|
3.0
|
52.9
|
1.0
|
O
|
B:VAL302
|
3.1
|
49.0
|
1.0
|
O
|
D:VAL302
|
3.1
|
48.9
|
1.0
|
C
|
C:VAL302
|
3.6
|
48.0
|
1.0
|
C
|
A:VAL302
|
3.6
|
48.7
|
1.0
|
C
|
D:VAL302
|
3.7
|
48.9
|
1.0
|
C
|
B:VAL302
|
3.7
|
49.0
|
1.0
|
K
|
A:K1212
|
3.8
|
47.5
|
0.5
|
C
|
D:THR301
|
3.9
|
53.1
|
1.0
|
C
|
A:THR301
|
3.9
|
52.9
|
1.0
|
C
|
B:THR301
|
3.9
|
53.5
|
1.0
|
C
|
C:THR301
|
3.9
|
52.9
|
1.0
|
CA
|
C:VAL302
|
4.0
|
48.0
|
1.0
|
CA
|
A:VAL302
|
4.1
|
48.7
|
1.0
|
CA
|
D:VAL302
|
4.1
|
48.9
|
1.0
|
CA
|
B:VAL302
|
4.1
|
49.0
|
1.0
|
N
|
A:VAL302
|
4.4
|
48.7
|
1.0
|
N
|
D:VAL302
|
4.4
|
48.9
|
1.0
|
N
|
C:VAL302
|
4.4
|
48.0
|
1.0
|
N
|
B:VAL302
|
4.4
|
49.0
|
1.0
|
N
|
A:GLY303
|
4.5
|
47.6
|
1.0
|
N
|
C:GLY303
|
4.5
|
47.3
|
1.0
|
N
|
D:GLY303
|
4.6
|
48.2
|
1.0
|
N
|
B:GLY303
|
4.6
|
48.5
|
1.0
|
CA
|
A:GLY303
|
4.9
|
47.6
|
1.0
|
CA
|
C:GLY303
|
4.9
|
47.3
|
1.0
|
CA
|
D:THR301
|
5.0
|
53.1
|
1.0
|
CA
|
A:THR301
|
5.0
|
52.9
|
1.0
|
CA
|
D:GLY303
|
5.0
|
48.2
|
1.0
|
|
Potassium binding site 4 out
of 6 in 7pxh
Go back to
Potassium Binding Sites List in 7pxh
Potassium binding site 4 out
of 6 in the Emodepside-Bound Drosophila Slo Channel
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K1212
b:47.5
occ:0.50
|
O
|
C:THR301
|
2.9
|
52.9
|
1.0
|
OG1
|
B:THR301
|
3.0
|
53.5
|
1.0
|
O
|
A:THR301
|
3.0
|
52.9
|
1.0
|
O
|
B:THR301
|
3.0
|
53.5
|
1.0
|
O
|
D:THR301
|
3.0
|
53.1
|
1.0
|
OG1
|
D:THR301
|
3.0
|
53.1
|
1.0
|
OG1
|
A:THR301
|
3.0
|
52.9
|
1.0
|
OG1
|
C:THR301
|
3.2
|
52.9
|
1.0
|
CB
|
A:THR301
|
3.5
|
52.9
|
1.0
|
CB
|
B:THR301
|
3.5
|
53.5
|
1.0
|
CB
|
D:THR301
|
3.5
|
53.1
|
1.0
|
K
|
A:K1213
|
3.6
|
75.7
|
0.2
|
CB
|
C:THR301
|
3.7
|
52.9
|
1.0
|
K
|
A:K1211
|
3.8
|
41.5
|
0.5
|
C
|
B:THR301
|
4.0
|
53.5
|
1.0
|
C
|
A:THR301
|
4.0
|
52.9
|
1.0
|
C
|
C:THR301
|
4.0
|
52.9
|
1.0
|
C
|
D:THR301
|
4.0
|
53.1
|
1.0
|
CA
|
A:THR301
|
4.4
|
52.9
|
1.0
|
CA
|
B:THR301
|
4.4
|
53.5
|
1.0
|
CA
|
D:THR301
|
4.4
|
53.1
|
1.0
|
CA
|
C:THR301
|
4.5
|
52.9
|
1.0
|
CG2
|
A:THR301
|
4.7
|
52.9
|
1.0
|
CG2
|
B:THR301
|
4.7
|
53.5
|
1.0
|
CG2
|
D:THR301
|
4.7
|
53.1
|
1.0
|
CG2
|
C:THR301
|
5.0
|
52.9
|
1.0
|
O
|
B:SER300
|
5.0
|
57.7
|
1.0
|
O
|
D:SER300
|
5.0
|
55.8
|
1.0
|
|
Potassium binding site 5 out
of 6 in 7pxh
Go back to
Potassium Binding Sites List in 7pxh
Potassium binding site 5 out
of 6 in the Emodepside-Bound Drosophila Slo Channel
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 5 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K1213
b:75.7
occ:0.25
|
O10
|
B:8I21209
|
3.2
|
86.5
|
1.0
|
O30
|
B:8I21209
|
3.3
|
86.5
|
1.0
|
K
|
A:K1212
|
3.6
|
47.5
|
0.5
|
O41
|
B:8I21209
|
3.8
|
86.5
|
1.0
|
C88
|
B:8I21209
|
3.8
|
86.5
|
1.0
|
OG1
|
A:THR301
|
3.9
|
52.9
|
1.0
|
OG1
|
C:THR301
|
3.9
|
52.9
|
1.0
|
N6
|
B:8I21209
|
4.0
|
86.5
|
1.0
|
C9
|
B:8I21209
|
4.0
|
86.5
|
1.0
|
O20
|
B:8I21209
|
4.2
|
86.5
|
1.0
|
OG1
|
B:THR301
|
4.2
|
53.5
|
1.0
|
C65
|
B:8I21209
|
4.2
|
86.5
|
1.0
|
OG1
|
D:THR301
|
4.3
|
53.1
|
1.0
|
C39
|
B:8I21209
|
4.3
|
86.5
|
1.0
|
C4
|
B:8I21209
|
4.4
|
86.5
|
1.0
|
O25
|
B:8I21209
|
4.4
|
86.5
|
1.0
|
O40
|
B:8I21209
|
4.4
|
86.5
|
1.0
|
C7
|
B:8I21209
|
4.5
|
86.5
|
1.0
|
C29
|
B:8I21209
|
4.5
|
86.5
|
1.0
|
C2
|
B:8I21209
|
4.7
|
86.5
|
1.0
|
C24
|
B:8I21209
|
4.7
|
86.5
|
1.0
|
CB
|
A:THR301
|
4.8
|
52.9
|
1.0
|
CB
|
C:THR301
|
4.9
|
52.9
|
1.0
|
C19
|
B:8I21209
|
4.9
|
86.5
|
1.0
|
O11
|
B:8I21209
|
5.0
|
86.5
|
1.0
|
|
Potassium binding site 6 out
of 6 in 7pxh
Go back to
Potassium Binding Sites List in 7pxh
Potassium binding site 6 out
of 6 in the Emodepside-Bound Drosophila Slo Channel
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 6 of Emodepside-Bound Drosophila Slo Channel within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K1209
b:54.1
occ:0.25
|
O
|
C:TYR304
|
4.2
|
51.6
|
1.0
|
O
|
B:TYR304
|
4.2
|
52.8
|
1.0
|
O
|
D:TYR304
|
4.2
|
53.2
|
1.0
|
O
|
A:TYR304
|
4.2
|
52.0
|
1.0
|
K
|
A:K1209
|
4.3
|
42.7
|
0.5
|
CA
|
C:GLY305
|
4.8
|
56.8
|
1.0
|
CA
|
B:GLY305
|
4.8
|
56.2
|
1.0
|
CA
|
D:GLY305
|
4.9
|
57.9
|
1.0
|
CA
|
A:GLY305
|
4.9
|
56.0
|
1.0
|
O
|
C:GLY305
|
5.0
|
56.8
|
1.0
|
O
|
A:GLY305
|
5.0
|
56.0
|
1.0
|
C
|
C:GLY305
|
5.0
|
56.8
|
1.0
|
|
Reference:
T.Raisch,
A.Brockmann,
U.Ebbinghaus-Kintscher,
J.Freigang,
O.Gutbrod,
J.Kubicek,
B.Maertens,
O.Hofnagel,
S.Raunser.
Small Molecule Modulation of the Drosophila Slo Channel Elucidated By Cryo-Em To Be Published.
DOI: 10.1038/S41467-021-27435-W
Page generated: Mon Aug 12 20:26:21 2024
|