Potassium in PDB 7l1a: Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp)

Enzymatic activity of Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp)

All present enzymatic activity of Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp):
2.5.1.6;

Protein crystallography data

The structure of Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp), PDB code: 7l1a was solved by C.N.Niland, E.Fedorov, V.L.Schramm, A.Ghosh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 18.92 / 1.25
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 68.113, 94.148, 117.237, 90, 90, 90
R / Rfree (%) 12.3 / 14.1

Other elements in 7l1a:

The structure of Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp) also contains other interesting chemical elements:

Sodium (Na) 7 atoms
Magnesium (Mg) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp) (pdb code 7l1a). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp), PDB code: 7l1a:

Potassium binding site 1 out of 1 in 7l1a

Go back to Potassium Binding Sites List in 7l1a
Potassium binding site 1 out of 1 in the Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human Methionine Adenosyltransferase 2A Bound to Methylthioadenosine and Inhibitor, Di-Imido Triphosphate (Pnpnp) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:11.3
occ:1.00
 O1B A:XE1404 2.5 9.4 1.0
H1B1 A:XE1404 2.6 11.3 1.0
OD1 A:ASP258 2.7 13.4 0.6
O A:ALA259 2.8 9.2 1.0
O A:HOH528 3.1 9.9 1.0
O A:HOH503 3.2 33.6 1.0
O A:HOH527 3.2 10.6 1.0
CG A:ASP258 3.5 12.5 0.7
HB3 A:ALA259 3.6 10.3 1.0
MG A:MG401 3.7 4.8 1.0
OD2 A:ASP258 3.7 13.1 0.6
H A:ALA259 3.9 9.2 1.0
HB1 A:XE1404 3.9 11.2 1.0
C A:ALA259 3.9 7.0 1.0
PB A:XE1404 4.0 9.3 1.0
HH22 A:ARG264 4.1 15.7 1.0
N A:ALA259 4.1 7.6 1.0
O2B A:XE1404 4.2 9.5 1.0
CA A:ALA259 4.4 7.2 1.0
CB A:ALA259 4.4 8.6 1.0
NH2 A:ARG264 4.4 13.1 1.0
HH21 A:ARG264 4.6 15.7 1.0
N A:ALA406 4.6 22.5 1.0
C A:ASP258 4.6 8.2 1.0
H2B1 A:XE1404 4.7 11.4 1.0
HA2 A:GLY260 4.7 7.8 1.0
HA A:ASP258 4.8 11.3 1.0
CB A:ASP258 4.8 11.4 1.0
N3A A:XE1404 4.9 8.4 1.0
HB1 A:ALA259 4.9 10.3 1.0
CA A:ASP258 5.0 9.4 1.0

Reference:

C.N.Niland, A.Ghosh, S.M.Cahill, V.L.Schramm. Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A. Biochemistry 2021.
ISSN: ISSN 0006-2960
PubMed: 33656855
DOI: 10.1021/ACS.BIOCHEM.0C00998
Page generated: Sat Apr 3 16:11:49 2021

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy